Studying different angles of cancer pathogenesis and development benefits from measuring related samples at different molecular levels. I will describe studies that involve the measurement of serum glycomics, miRNA and transcriptomics. Synthetic oligonucleotide libraries are being used in molecular measurement for several years in the context of sample enrichment for sequencing. More applications that support the understanding of cellular regulation in different contexts are now emerging and will also be described. In the examples I will emphasize the use of statistics for ranked lists to enhance the data interpretation and to improve the knowledge extraction.