My team's research explores how neurons integrate information and how cooperative activity gives rise to high-level brain function and dysfunction. In my presentation I'll discuss our approach which is best described by the triptych “signals, systems and psyche”: by detailed comprehension of signals elicited by the brain, we seek to understand computation during a behavioral task (systems) and how such processing gives rise to a high-level, behavioral readout (psyche). To this end we use a combination of methods such as large-scale biophysically detailed simulations as well as slice and in vivo electrophysiology.