We will introduce basic concepts of cancer biology and algorithmic challenges in the analysis of molecular profiles obtained from tumors. Emphasis will be placed on methods for assessing the extensive heterogeneity that is present both within and among tumors, a major obstacle to successful treatment. Specifically, we will address computational approaches to infer genomic variation from tumor sequencing data, to reconstruct the evolutionary history of individual tumors, and to estimate models of tumor progression.

The first session of this mini course will take place on Wednesday, January 20 from 2:00 pm – 3:30 pm; the third session of this mini course will take place on Thursday, January 21 from 9:00 am – 10:00 am.