Bin Yu is the head of the Yu Group at Berkeley, which consists of 15-20 students and postdocs from Statistics and EECS. She was formally trained as a statistician, but her research interests and achievements extend beyond the realm of statistics. Together with her group, her work has leveraged new computational developments to solve important scientific problems by combining novel statistical machine learning approaches with the domain expertise of my many collaborators in neuroscience, genomics and precision medicine. They also develop relevant theory to understand random forests and deep learning for insight into and guidance for practice.